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{
  "id": "NCT00001480",
  "type": "Study",
  "data": {
    "briefSummary": "The purpose of this study is to evaluate people with mild memory problems, those with dementia, those at risk for developing Alzheimer's disease (AD), and healthy volunteers to identify markers of AD before the changes that occur with the disease begin.\n\nThe origin and markers of progression for Alzheimer's disease (AD) are relatively obscure. Despite increased understanding of the underlying biology of AD, its clinical diagnosis is still made only after progressive cognitive decline; definitive diagnosis is confirmed at autopsy. This study will examine biomarker changes over time in a distinct cohort of people with an increased risk of developing AD. The study will also identify and track biological changes that occur with progressive dementia and compare those changes to the known cognitive and emotional disturbances that characterize AD.\n\nIndividuals with a first-degree relative with AD will be recruited into an at-risk cohort. They will be followed and compared to a group of healthy volunteers for a minimum of 8 years.",
    "completionDate": "2007-03-31",
    "conditions": [
      "Alzheimer's Disease",
      "Dementia",
      "Healthy",
      "Memory Disorder"
    ],
    "enrollmentCount": 750,
    "enrollmentType": null,
    "nctId": "NCT00001480",
    "phase": null,
    "sponsorId": "national-institute-of-mental-health-nimh",
    "startDate": "1995-03-21",
    "status": "COMPLETED",
    "studyType": "OBSERVATIONAL",
    "title": "The Evaluation and Follow-up of Patients With Memory Disorder and Normal Controls",
    "url": "https://clinicaltrials.gov/study/NCT00001480"
  }
}